NEURODEGENERATIVE DISEASES IN UZBEKISTAN: CAUSES OF SPREAD AND REACTIVE ASTROCYTE CHANGES IN DISEASE PROGRESSION
DOI:
https://doi.org/10.47390/ydif-y2026v2i2/n68Keywords:
neurodegenerative diseases, astrocytes, reactive gliosis, neurodegeneration, epidemiology.Abstract
Neurodegenerative diseases are a group of disorders of the central nervous system that develop with progressive and irreversible damage to its structure and function. Today, they have become a pressing issue for medicine and healthcare systems worldwide. The accelerated aging process of the population, or the increasing speed of population aging, has led to a significant rise in the prevalence of neurodegenerative diseases globally. This study highlights the causes of neurodegenerative diseases, their epidemiological aspects both globally and within Uzbekistan, as well as the pathogenetic significance of reactive changes in astrocytes.
References
1. De Strooper B., Karran E. The cellular phase of Alzheimer’s disease // Cell. – 2016. – Vol. 164. – P. 603–615. (Fundamental source)
2. Henstridge C. M., Hyman B. T., Spires-Jones T. L. Glial contributions to neurodegeneration // Nature Reviews Neuroscience. – 2021. – Vol. 22. – P. 447–460.
3. Hickman S., Izzy S., Sen P., Morsett L., El Khoury J. The microglial sensome revealed by direct RNA sequencing // Nature Neuroscience. – 2020. – Vol. 23. – P. 1073–1083.
4. Keren-Shaul H., Spinrad A., Weiner A., et al. A unique microglia type associated with restricting development of Alzheimer’s disease // Cell. – 2017. – Vol. 169. – P. 1276–1290.
5. Leng F., Edison P. Neuroinflammation and microglial activation in Alzheimer disease // Nature Reviews Neurology. – 2021. – Vol. 17. – P. 157–172.
6. Liddelow S. A., Guttenplan K. A., Clarke L. E., et al. Neurotoxic reactive astrocytes are induced by activated microglia // Nature Neuroscience. – 2017. – Vol. 20. – P. 1371–1380.
7. Shi Y., Holtzman D. M. Interplay between innate immunity and Alzheimer disease // Nature Reviews Immunology. – 2024. – Vol. 24. – P. 1–16.
8. Smith H. L., Freeman O. J., Butovsky O. Astrocyte dysfunction in amyotrophic lateral sclerosis // Brain. – 2022. – Vol. 145. – P. 364–379.
9. Sofroniew M. V. Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity // Trends in Immunology. – 2020. – Vol. 41. – P. 758–770.
10. Tansey M. G., Goldberg M. S. Neuroinflammation in Parkinson’s disease // The Lancet Neurology. – 2020. – Vol. 19. – P. 942–953.
This work is licensed under a 